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Online ISSN:-2394-4994


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Received : 18-12-2020

Accepted : 30-01-2021

Available online : 01-06-2021

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Effect of dexmedetomidine on hemodynamic and recovery responses during tracheal extubation

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Original Article

Author Details : Shabeel Aboobacker C P, Shamjith Kunikkakath*, Melbin Baby, Salman Mohammed Kutty C

Volume : 8, Issue : 2, Year : 2021

Article Page : 310-315

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Introduction: Endotracheal extubation is associated with cardiovascular and airway responses leading to tachycardia, hypertension, arrhythmias, myocardial ischemia, coughing, agitation, bronchospasm, increased bleeding, raised intracranial and intraocular pressure which may be life threatening especially in vulnerable patients. Dexmedetomidine, a highly selective ?2-adrenoreceptor agonist is found to attenuate these effects and provide a smooth extubation.
Objective: To assess the effect of dexmedetomidine on hemodynamic and ventilatory recovery during tracheal extubation.
Materials and Methods: This comparative study was done in 42 patients who fulfilled the inclusion and exclusion criteria between the age group of 20 to 45 years from both sexes were randomly allocated in to two groups of 21 each. One group received 0.5mg Dexmedetomidine and the other group received 100 ml NS. Both groups were compared for the hemodynamic parameters at different time intervals during the whole procedure and were compared for differences if any.
Results: In the study group, parameters like Mean arterial pressure, Systolic Blood Pressure, Diastolic Blood Pressure and Heart Rate were under control than the control group. The extubation quality score between controls and dexmedetomidine group (2.14 vs. 1.24) is statistically significant (P<0> Conclusion: Just before extubation, administration of dexmedetomidine ensures the smooth extubation of the trachea and reduces the cardiovascular responses. It also provides adequate sedation postoperatively.

Keywords: Dexmedetomidine, Bradycardia, Hemodynamic responses, Tracheal extubation.

How to cite : Shabeel Aboobacker C P, Kunikkakath S , Baby M , Salman Mohammed Kutty C, Effect of dexmedetomidine on hemodynamic and recovery responses during tracheal extubation. Indian J Clin Anaesth 2021;8(2):310-315

Copyright © 2021 by author(s) and Indian J Clin Anaesth. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (